The U.S. healthcare system is among the most advanced in the world, but millions still face barriers to quality care due to cost, access, or social inequities. That’s where healthcare-focused NGOs step in. From offering free clinics to advocating for mental health and chronic disease management, these nonprofit organizations are reshaping lives and communities. Here are the top 10 healthcare NGOs in the United States in 2025, based on impact, reach, and public health contributions.
1. Partners In Health (PIH)
Headquarters: Boston, MA
Focus Areas: Global health, infectious diseases, maternal health
Highlights:
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Operates in underserved U.S. regions and globally
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Focuses on social justice and healthcare equity
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Leading response organization for epidemics and disaster relief
2. Direct Relief
Headquarters: Santa Barbara, CA
Focus Areas: Emergency medical aid, disaster response, public health
Highlights:
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Distributes medical supplies and resources in all 50 states
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Provided aid during hurricanes, wildfires, and COVID-19
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Ranked among the top U.S. charities for efficiency and impact
3. Americares
Headquarters: Stamford, CT
Focus Areas: Primary care, chronic disease, mental health
Highlights:
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Runs free clinics for low-income and uninsured patients
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Offers mental health training for frontline workers
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Responds to emergencies with medicine and medical personnel
4. Planned Parenthood Federation of America
Headquarters: New York, NY
Focus Areas: Women’s health, reproductive care, sexual education
Highlights:
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Offers healthcare to over 2 million people annually
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Provides cancer screenings, STI testing, and birth control
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Strong advocacy for healthcare access and rights
5. The Carter Center – Mental Health Program
Headquarters: Atlanta, GA
Focus Areas: Mental health awareness, policy reform, community healing
Highlights:
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Founded by former U.S. President Jimmy Carter
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Pioneers in mental health destigmatization and peer recovery programs
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Works on improving mental health systems in underserved areas
6. HealthWell Foundation
Headquarters: Germantown, MD
Focus Areas: Financial assistance for chronic illnesses
Highlights:
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Provides copay, insurance premium, and medication cost assistance
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Supports patients with cancer, autoimmune disorders, and rare diseases
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Highly rated for transparency and donor trust
7. National Alliance on Mental Illness (NAMI)
Headquarters: Arlington, VA
Focus Areas: Mental health support, education, policy advocacy
Highlights:
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Provides peer-led programs, helplines, and public awareness campaigns
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Offers support groups for families and individuals with mental illness
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Influential voice in mental health policy reform in the U.S.
8. Remote Area Medical (RAM)
Headquarters: Rockford, TN
Focus Areas: Mobile clinics, vision and dental care, underserved communities
Highlights:
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Offers free pop-up medical clinics across rural America
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Serves uninsured and underinsured populations
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Volunteer-based with thousands of medical professionals
9. MAP International
Headquarters: Brunswick, GA
Focus Areas: Essential medicine distribution, health systems strengthening
Highlights:
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Distributes medicines and medical supplies to free clinics and disaster zones
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Supports domestic and international health programs
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Trusted for delivering high-impact aid to communities in need
10. National Association of Free & Charitable Clinics (NAFC)
Headquarters: Alexandria, VA
Focus Areas: Free clinics, health equity, volunteer-based care
Highlights:
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Supports 1,400+ clinics across the U.S.
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Focus on chronic disease management, dental, and preventive care
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Improves access for millions of uninsured and low-income individuals
